mHealth for transgender and gender-expansive youth: harnessing gender-affirmative cross-disciplinary innovations to advance HIV prevention and care interventions
Review Article

mHealth for transgender and gender-expansive youth: harnessing gender-affirmative cross-disciplinary innovations to advance HIV prevention and care interventions

Simone J. Skeen1, Demetria Cain1, Kristi E. Gamarel2, Lisa Hightow-Weidman3, Cathy J. Reback4,5

1PRIDE Health Research Consortium, Hunter College of the City University of New York, New York, NY, USA; 2Department of Health Behavior & Health Education, University of Michigan School of Public Health, Ann Arbor, MI, USA; 3Institute for Global Health and Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; 4Friends Research Institute, Inc., Los Angeles, CA, USA; 5Department of Family Medicine, Center for HIV Identification, Prevention and Treatment Services, University of California Los Angeles, Los Angeles, CA, USA

Contributions: (I) Conception and design: All authors; (II) Administrative support: All authors; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: SJ Skeen; (V) Data analysis and interpretation: SJ Skeen; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

Correspondence to: Simone J. Skeen. PRIDE Health Research Consortium, Hunter College of the City University of New York, New York, NY, USA. Email:

Abstract: Transgender and gender-expansive (TGE) youth endure stark disparities in health and wellbeing compared to their cisgender peers. A key social determinant of health for TGE adolescents and emerging adults is gender affirmation, which encompasses multidimensional validations of an individual’s lived gender. Lacking available resources for one’s gender affirmation, TGE young people may engage in high-risk maladaptive coping behaviors, linked to their disproportionately high HIV-acquisition risk. A range of innovative mobile technologies are guided by the Gender-Affirmative Framework to promote the health of TGE communities, including through HIV prevention and care continuum outcomes. The aim of this review was to examine key features of existing mobile technologies that can be leveraged to advance the field of TGE-responsive mHealth. We systematically searched scientific records, gray literature, and the iOS and Android app distribution services. To be eligible, platforms and interventions needed to be tailored exclusively to a TGE user base, incorporate gender-affirming features, and be optimized for or adaptive to mobile technologies. Eligible interventions (N=24) were compared on evidence of utility, core functionalities, and dimensions of gender affirmation. Smartphone applications (apps) and webapps (n=16) were the most common delivery modality. Many interventions (n=9) aimed to address HIV-related outcomes and integrated gender-affirmative features. The most common gender-affirmative features originated in fields of human-computer interactions and informatics, or were crowdfunded by TGE developers. HIV-focused interventions incorporated evidence-based health behavior change strategies and utilized rigorous evaluation methods. Across modalities and disciplines, behavioral self-monitoring and access to HIV prevention services were the most frequent features. Over two-thirds of the interventions reviewed aimed to provide medical gender affirmation (e.g, provided guidance on obtaining medically sanctioned hormone therapies, or safely practicing non-medical options such as chest-binding) or psychological gender affirmation (e.g, provided linkage to mental health counseling). Our results show that mHealth and other technology-mediated interventions offer a diverse range of both evidence-based and innovative features; however, many have not been rigorously evaluated in a randomized controlled trial to support TGE users. A continuing commitment to evidence-based health behavior change strategies, exemplified by the HIV-focused interventions included in this review, is essential to advancing gender-affirmative mHealth. The unique and highly innovative features of platforms originating outside the fields of HIV prevention and care suggest new directions for TGE-responsive mHealth, and the need for more conscientious models of knowledge exchange with investigators across scientific disciplines, private-sector developers, and potential users.

Keywords: Gender affirmation; HIV; human-computer interactions; mHealth; technology; transgender; youth

Received: 07 February 2020; Accepted: 03 June 2020; Published: 20 April 2021.

doi: 10.21037/mhealth-20-60


Despite some advances in public awareness and legal protections, transgender and gender-expansive (TGE) youth continue to face grave health inequities that stem from multiple sources, such as biased and exclusionary laws and policies, societal discrimination, and a lack of access to quality and affirming health care (1), increasing their risk for HIV acquisition (2): among transgender people living with HIV in the U.S, 36.3% were youth under the age of 24 (3). The field of HIV prevention is increasingly moving towards technology-mediated interventions for youth, as mobile health (mHealth) and electronic health (eHealth) are easily accessible and can be delivered in real time (4). However, despite the promise of technology-mediated interventions, there has been limited focus on how these interventions can be harnessed to address HIV prevention and care for TGE youth (5,6).

This review was specifically focused on youth who fall under the umbrella of TGE, including those who may be actively questioning their gender (7,8). To clarify our discussion, we begin by providing some key definitions; however, these brief descriptions may not capture all of the nuances in this rapidly evolving field. “Sex”, or “natal gender”, is a label, which is generally defined as “male” or “female”, that is assigned at birth, while, “gender identity” is one’s inherent sense of self, which results from a multifaceted interaction of biological traits, developmental factors, and societal context (9). “Gender expression” refers to the different ways people display their gender through clothing, hair styles, mannerisms, or social roles (10).

These labels may or may not be congruent. The term “cisgender” is used when someone identifies with and expresses a gender that is consistent with the culturally defined norms of the sex that was assigned to them at birth (11). “Transgender” is usually reserved for the subset of individuals whose internal gender identity is inconsistent with the sex assigned on their birth certificate (12). These terms are not diagnoses but are instead personal and often dynamic ways of describing one’s gender experience. “Gender diverse” or “gender expansive” are umbrella terms that individuals may apply when their gender identity, expression, or physical attributes do not conform to the norms and stereotypes others expect of their assigned sex (13). More recently, the terms “nonbinary” or “genderqueer” have been adopted within scientific discourse and among many TGE communities to refer to individuals who do not conform to binary conceptualizations of gender as either male or female (14). In this review, we intentionally use the terms TGE to describe all non-cisgender youth, as some people use multiple gender identities and, additionally, some gender identities change across one’s life course. For example, some nonbinary people identify as transgender; however, others do not (8). Thus, the term gender-expansive provides a means to begin to accommodate different experiences, expressions, and self-identifications (8).

Although few probability studies assess gender identity, it’s been estimated that 0.7% to 3.2% of youth identify as transgender (15,16). These adolescents and emerging adults can find social inclusion elusive, and may lack access to tailored health resources. A recent nationally representative survey of 5,765 TGE teens, ages 13–17, found that less than a quarter feel safe being themselves at home and in school; 72% have heard their families make denigrating remarks toward sexual and gender minorities; and 84% have been threatened at school, a setting in which only 10% reported receiving safer sex information responsive to their lives and identities (8). TGE youth, particularly youth of color, are also at substantial risk of a multitude of adverse outcomes, with 25–43% experiencing unstable housing/homelessness (17,18), 66% enduring unemployment (18,19), 67% engaging in survival sex (17), and 1 in 10 surviving physical assault (20). To date, the majority of research among TGE youth has focused on the role stigma and discrimination play in creating or exacerbating these adverse social and health conditions (21).

More recently, the field has moved towards embracing gender affirmation as a key social determinant of health for gender-expansive people (22,23). The “Gender Affirmation Framework refers to a multifaceted and often long-term process through which TGE individuals align their internal senses of embodiment and external expressions of culturally bound gender norms with their inherent gender identities (24). Not getting gender affirmation needs met across different dimensions such as medical (e.g, exogenous hormone therapy to develop a more gender-congruent sense of embodiment, including through physical features), social (i.e, use of correct name and pronouns), psychological (i.e, perceptions of respect), and legal (i.e, name change documentation) can place TGE youth at increased risk of emotional distress, suicidality, sexual risk behaviors, medical mistrust (23,25,26), and serve as a barrier to engaging in HIV prevention and care (27). According to the Gender Affirmation Framework (24), lacking accessible sources of gender affirmation, TGE individuals may seek validation of their emerging identities through high-risk behaviors such as condomless anal sex (CAS) and bodily modifications in non-medical settings. TGE youth have reported rates of CAS between 27–48% and non-medical injection of hormones or silicone between 24–27% (28). Widespread stigma, sexism, and other vectors of oppression place already marginalized subpopulations, such as TGE youth of color, at particularly high risk of HIV acquisition (24). Given the complex risk profiles of many TGE communities, innovative approaches that address both gender affirmation and HIV prevention and care are needed.

Technology engagement among TGE youth

Teenagers across the LGBTQ spectrum report spending an average of 5 hours online every day, 45 minutes longer than their non-LGBTQ peers, with 76% preferring online chat or text message options when seeking support in a crisis (29,30). Within the LGBTQ spectrum, 26% of transgender youth communicate online with LGBTQ friends daily or almost daily, while 20% or less of their cisgender peers exhibit similar frequency. Using the internet to acquire health information was near-universal among transgender youth: 95% report doing so, versus 80% or less of their LGB peers. In regards to accessing HIV/AIDS and STI information online, transgender youth were outpaced only by cisgender gay and bisexual young men (29). Given these patterns of technology use (4,5,31), technology-mediated modalities are ideal for delivering gender-affirming health interventions to TGE young people, including interventions focused on HIV prevention and care. Social media, and other online venues that enable peer-to-peer interaction, selective self-presentation, and the sharing of user-generated content (32,33), can be essential sources of gender affirmation for TGE youth (34-36).

The features of these platforms can subvert the isolation and routine invalidations endured by TGE youth who do not have access to affirming homes or schools. For example, TGE Tumblr users can obtain social connection by making meaning of their experiences, establishing peer-to-peer “care structures” navigable via an array of gender-specific hashtags (37,38). TGE youth and their caregivers can equip themselves with clarifying terminologies and discover both on- and offline support networks through listservs, social forums, and the websites of local nonprofits (39). But the unique features of online platforms also enable harms that disproportionately impact TGE communities. Cyberbullying, harassment, stalking, and other abusive online behaviors are directed toward TGE youth at disparate rates (40). Many, as a result, may feel anxious, depressed, or suicidal (29,41,42). Misinformation and non-evidence-based anecdotes on gender-affirming care discoverable online can jeopardize TGE young people’s wellbeing (39).

For many TGE youth, technology-mediated interventions are situated within this rich, yet fractious, online milieu, in which TGE youth spend approximately 5 hours daily (29). Recent mHealth interventions, which aim to build upon evidence-based bio-behavioral HIV prevention strategies, intend to activate this online milieu to advance the health and wellbeing of these vulnerable communities (43). Notably, the field of HIV prevention is not alone in advancing gender-affirming mobile interventions for TGE communities. The importance of gender affirmation in promoting the health and wellbeing of TGE communities has driven the development of other, distinct lineages of technology-mediated interventions tailored toward the needs of TGE communities (44,45). Often, these platforms are aligned with human-computer interaction (HCI) disciplines, or rely on crowdfunding, open-source architectures, and robust community engagement for sustainment (46-48). The core functionalities of these platforms intend to aid TGE users in affirming their gender identities and navigating their lives safely as TGE individuals (45,49). Notably, the functionalities often do not explicitly engage with traditional HIV prevention and care strategies; however, their emphases on gender affirmation is aligned with contemporary understandings of HIV acquisition among high-risk TGE populations. Specifically, these functionalities frame HIV transmission risk behaviors as maladaptive attempts to attain gender affirmation in oppressive, invalidating settings, where safer sources of validation are unavailable (24).

As such, a cross-disciplinary scoping review of smartphone-based, SMS, telemedicine, and other TGE-focused mobile technology-mediated interventions has the potential to provide new directions in honing the next generation of mHealth designed to improve HIV prevention and care with and for TGE youth. The present review aims to identify and describe a diverse catalog of technological platforms guided by the tenets of the Gender Affirmation Framework. In doing so, we adopt the lens of Affordance Theory, which views technological features in terms of imagined affordances: the human-perceptible actions and possibilities inherent in new technologies, emphasizing the previously inconceivable expectations and socio-cultural meanings they may accrue over time. “Human-perceptible”, in this context, refers to possibilities that the end-user is aware of and, therefore, may integrate into their daily lives (50). Thus, a focus on affordances foregrounds new potentials that rely on the unique interplays between human and technological agency (51).


We used the Arksey and O’Malley five-stage framework for scoping review studies (52,53). A scoping review was chosen over a systematic review so that we could include a broad range of technology-mediated interventions, use a multi-pronged search strategy to capture traditional clinical trials (in progress, where necessary), and community-derived innovations across disciplines. We did not place any restrictions on publication type. In this, our approach is consistent with recent scoping reviews in mHealth and eHealth (54-57).

Stage 1: identifying the research question

The rationale for the review arose from the discontinuity and lack of knowledge sharing in the areas of gender-affirmative technology-mediated interventions evident across disciplines—specifically, between HIV-focused mHealth and parallel developments in informatics, HCI, and outside of traditional research infrastructures entirely. Our objective was to analyze these rich but varied advances through a single lens, guided by the Gender Affirmation Framework, and the abovementioned concept of imagined affordances.

Thus, the research question guiding our scoping review was: “How has customized software, optimized for or adaptive to mobile technologies (including mHealth), aimed to advance the health and wellbeing of young TGE communities by affirming their lived genders?

The conceptualization of our key terms, in emulation of the format presented by Adepoju et al. (58), are shown in Table 1.

Table 1
Table 1 Conceptualization of key terms in research question
Full table

Stage 2: identifying relevant studies

To capture empirical articles, formative research, and other traditional publication types in medical, behavioral, and socio-technical science, PubMed, PsycINFO, and the ACM (Association for Computing Machinery) Digital Library were queried. To capture gray literature such as project reports, funding prospectuses, blogs, and popular media reporting, Google and DuckDuckGo (a search engine on the open web that forgoes the algorithmically personalized rankings that can render Google’s search results impossible to replicate) (63) were used. Recent reference lists were hand-searched by the first author (SJS). All records were compiled and screened using the Zotero reference manager (64).

Search terms were developed iteratively, based on pilot searches in Google Scholar. Our final terms comprised “trans*gender”, “genderqueer”, “non*binary”, “gender expansive”, “gender diverse”, “agender”, “youth”, “adolescent”, “online”, “web app”, “tech*”, “counsel*”, “HIV”, “health”, “mobile”, and “text message” alone and in combination. Results were unrestricted by date.

Additionally, Google Play and the App Store, the mobile app distribution services for the Android and iOS smartphone operating systems, respectively, were searched directly for software relevant to our abovementioned objective. Each was queried with the term “transgender”, and the full results were screened against our selection criteria.

Our search was limited to English-language reporting and platforms. All searches were undertaken initially by the first author (SJS) in August, 2019, with secondary title/abstract screening by a research intern (AP) in November, 2019. All databases were systematically re-queried, and our results updated, in April and May, 2020.

Finally, as the authors are involved in various roles within the UNC/Emory Center for Innovative Technology (iTech) (65), we were able to include the integrated TechStep platforms prior to any external reporting on that intervention.

Stage 3: study selection

The inclusion of mHealth and other platforms in this review was dependent on the selection criteria shown in Table 2. Out of our initial 565 candidate platforms identified via title/abstract screening, gray literature searches, app distribution services, and the iTech network, 24 were selected for inclusion. The complete process is illustrated in Figure 1.

Table 2
Table 2 Inclusion and exclusion criteria applied
Full table
Figure 1 Flow diagram illustrating the search and selection of commercially available and in-development or mid-evaluation platforms and interventions.

Stage 4: charting the data

Consistent with Arksey & O’Malley (52), we developed a descriptive-analytical summary of our findings, delineating key aspects of each platform for comparison, with a focus on distinguishing novel gender-affirming functionality. The respective platforms’ key features were categorized inductively by the first author with the aid of a consensus coder (AP).

The four recognized dimensions of gender affirmation were adapted from the typology of gender affirmation as a social determinant of health described by Reisner et al. (23), and defined in the previous section. Because many approaches to bodily gender affirmation (e.g, chest binders, electrolysis) can be accessed outside of medical settings, we replace “medical” with embodied in the present typology. These dimensions were assigned by the first author with the aid of a second consensus coder (PG). In both coding procedures, discrepancies were resolved in conference until unanimity was reached.

Stage 5: collating, summarizing, and reporting the results

We then compiled and summarized the results of each of the platforms and report on comparisons between platforms in the use of evaluation methods, theoretical grounding, key/unique features, and dimensions of gender affirmation.


The final sample included 24 platforms or interventions, in widely disparate phases of development. Their names and brief descriptions, modes of delivery, state of their evidence bases, theoretical groundings (if specified), key or noteworthy features, and the dimensions of gender affirmation they aim to engage, are presented in Table 3.

Table 3
Table 3 Summary of technology-mediated (N=24) interventions tailored for or inclusive of TGE youth
Full table

Outcomes and efficacy

Of the 24 platforms examined, nine included HIV prevention and treatment outcomes, with seven platforms HIV focused; three had undergone pilot studies that provided acceptability and feasibility outcomes, and only one used a fully powered randomized controlled trial (RCT) to evaluate intervention efficacy. One pilot study, Project Moxie, which is a remote video counseling intervention, found that approximately half of the total participants assigned to the intervention group took part in the counseling sessions; however, the TGE participants who did take part reported uniformly high rates of satisfaction with the counseling and software. Although sexual risk behaviors remained unchanged at 3 months, there was a significant increase in STI testing rates and PrEP acceptability among participants at 3 months (73). Trans Women Connected, a small acceptability and usability pilot study, showed increases in self-efficacy to access specialized and online support (102). Similarly, the unnamed Washington, DC–based telehealth intervention, which included HIV services among its referrals, showed increases in users’ intentions to seek TGE-affirming and other specialized care (104). Text Me, Girl!, which provided trans women with supportive text messages, demonstrated significant outcomes for increased antiretroviral treatment (ART) uptake, excellent ART adherence, and viral suppression among trans-feminine young adults (ages 18–34) living with HIV (97). As of May 2020, TechStep, with its webapp, SMS, and eCoaching platforms (which we reviewed independently) are in the midst of a randomized controlled trial to determine their efficacy in reducing behavioral risk for HIV/STI acquisition and encouraging PrEP uptake and adherence (43). The they2ze app, developed by the nonprofit YTH [Youth + Tech + Health (98)], and the QueerDoc telehealth service (75), both include linkages to HIV services. However, as of this writing, no data regarding intervention outcomes or efficacy have been reported for either platform.

The other platforms (n=15) whose primary aims did not focus explicitly on HIV prevention or care have not presented evaluation data to establish their efficacy or effectiveness. Many appeared to be early in development and pilot testing; thus, qualitative feasibility and acceptability data provided by small groups of target users was most commonly provided. For instance, U-Signal, an integrated smartphone-smartwatch platform designed to enable peer-to-peer alerts of imminent personal safety risks among trans-feminine and nonbinary communities of color, showed strong acceptability among seven TGE interviewees who reviewed the prototype (45). Trans Pelvic Health, a prototype iOS app that tracks key aspects of self-administered aftercare for gender-affirming genital surgeries (e.g, vaginoplasty), such as urinary frequency and routine Kegel exercises, show satisfactory preliminary usability among 10 pilot users, though it is unclear if these users were TGE (100). The exception was QueerViBE, which comprises a series of online educational modules, grounded in discursive analysis of TGE youth focus groups, and aiming to evoke self-esteem and positive transgender identity among its trans-masculine and nonbinary users, QueerViBE demonstrated preliminary efficacy using an RCT design; however, the study lacked follow-up measures beyond one month (44).

Theoretical grounding

Among the 24 platforms, six described their theoretical groundings, which were mostly focused on HIV (n=5), with the exception of QueerViBE. The two SMS-enabled interventions reviewed, TechStep: SMS and Text Me, Girl!, were grounded in the Health Belief Model, Social Cognitive Theory, and Social Support Theory, aiming to identify health-protective behaviors and health threats, bolster individuals’ self-efficacy, and embrace available instrumental, emotional, and informational supports, respectively (43,97). The TechStep: webapp intervention was developed based on the Information Motivation Behavioral Skills (IMB) model, which highlights the role of informational attainment and motivational drivers in the adoption of health-protective behaviors (91). Motivational interviewing (MI) guided both Project Moxie and TechStep: eCoaching; the latter of which employed a hybrid MI-Cognitive Behavioral Therapy (CBT) approach to empower TGE users through evoking their own capacities for self-determination and health-protective decision-making (6,43).

The only intervention not explicitly addressing HIV outcomes that provided evidence of a theoretical basis for development was QueerViBE, which, in line with its aims to enhance a multilevel framework of wellbeing, ranging from the individual to socio-political, integrates multiple social constructionist and queer theories. These include analyses on the social construction of masculinity (the platform was tailored for trans-masculine and nonbinary youth), its societally enforced norms (81), and their relations to visibility and power, interpreted through a Foucauldian lens (82,83). In addition, one module also incorporates CBT techniques, aiming to preserve users’ self-esteem when confronted with intrusive and invalidating questions from cisgender peers (44).

Dimensions of gender affirmation

All but one of interventions profiled (n=23) sought to address psychological dimensions of gender affirmation, by providing linkage to mental health counseling or by attempting to boost user self-esteem and/or self-efficacy. Fifteen interventions had features and resources aiding in social affirmation, which included, for example, features connecting TGE peers and mentors, and activating community networks and crowdsourced knowledge. Embodied affirmation was addressed in another 15 interventions through guidance on accessing hormones and safely undertaking non-medical bodily affirmation options. In more than half the interventions reviewed (n=15), psychological and social affirmation co-occurred, typically through core features designed to enhance both social supports and agentic, individual, wellbeing. These were evident in the webapps with social networking features (TechStep: webapp, Trans Women Connected, U-Signal) and the SMS-enabled interventions (TechStep: SMS and Text Me, Girl!). The embodied-psychological (n=13) and embodied-social (n=6) dimensions were less likely to co-occur. They appeared typically—though not exclusively—in the platforms that incorporate a broad range of resources for medical, mental health counseling, and community support referrals. Only six provided legal gender affirmation, typically through referrals to legal assistance options, with the exception of QMed, which provides required medical documents for legal gender-marker and name updates directly. Only Solace LGBT, TechStep: webapp, Trans Women Connected, and the Washington DC intervention engaged in all four dimensions recognized by the Reisner et al. (23) gender affirmation typology.

Key and unique features

The most frequently integrated features were behavioral self-monitoring (n=11), compilations of TGE-responsive brick-and-mortar resources (n=8), and informative content tailored by TGE stakeholders (n=7). TechStep: webapp and they2ze, both focused on HIV prevention and sexual health education among TGE users, were the most feature rich. HIV testing and counseling resources and remote video counseling were available almost exclusively within the HIV-prevention interventions, with the exception of the QueerDoc and Washington, DC–based telehealth interventions. Only Refuge Restrooms, Safe Transgender Bathroom App, the Spokane Trans Map, and U-Signal incorporate features designed to enhance personal safety: Refuge Restrooms (and similar platforms; see Table 3), through mapping all-gender and single-occupancy publicly accessible restrooms for users, who may fear harassment or violence in traditionally gendered spaces (47); and U-Signal, through its unique peer-to-peer alerts and the discretion with which they can be activated, silently, by smartwatch (45).


TGE young people endure compounded vulnerabilities to stigma, social isolation, violence, and HIV (9). While the adoption of digitally networked technologies among TGE youth is widespread, their online social milieu can be both robustly supportive and a site of invalidation and abuse (42). A diverse array of mobile technologies aims to promote TGE users’ health and wellbeing, primarily through gender-affirmative and HIV-prevention features. These interventions incorporate both traditional mHealth elements, such as behavioral tracking and hyperlocal referrals, and highly innovative platform-specific features, tailored for a TGE user base. This review examined these interventions by evaluation methods, dimension of gender affirmation, feature profiles, and their respective evidence bases.

The most evident distinction between disciplines is the commitment to randomized controlled trials of efficacy, which was all but unique to the HIV-prevention interventions. These platforms, through government funding and accountability structures, and the involvement of university-affiliated investigators, require “gold-standard” evidence of their efficacy and effectiveness via longitudinal and resource-intensive trials (105). Translationally, this distinction is paramount, as future funding, widespread dissemination, and the resources for adaptation rely on established efficacy. For example, Project Moxie, TechStep (across modalities), Text Me, Girl!, and Trans Women Connected are supported by research infrastructures able to rigorously assess feasibility, acceptability, and efficacy outcomes (65). The app and webapp interventions focused on HIV prevention and care also possessed the most features among the interventions reviewed. Additionally, they2ze, TechStep, and Trans Women Connected, all integrate a spectrum of high-quality curated resources conscientiously tailored for their target TGE users.

On the contrary, the HIV-prevention interventions lack the unique, core affordances that have guided the conspicuously leaner non-HIV-focused platforms. Refuge Restrooms and Safe Transgender Bathroom App, for example, perform a single function (locate restrooms). But through this single function, they reliably create new possibilities for personal safety among their users. This leanness, even if it sacrifices functional heterogeneity, enables access for lower socioeconomic status and transient users, who may share devices, use lower-specification hardware, or be subject to intermittent connectivity and power outages (106). The features exclusive to the non-HIV-focused platforms focus on within-person drivers of gender affirmation. Some of these platforms are narrow in focus [Trans Memo, Binder Reminder (46,99)], whereas others seek to holistically address gender affirmation needs [EVA, Solace, TransTracks (48,49,89)], Others acknowledge the often-politicized meanings that TGE communities may attach to—or have imposed upon—their identities [QueerViBE, U-Signal (44,45)]. Together, the non-HIV-focused platforms included in this review illustrate the importance of routine self-validation and physical safety as critical needs for TGE youth. Thus, while low-threshold hormone access is a key component of TGE wellbeing (as QMed recognizes), it is distinct, experientially, from the routinely accessible and cumulative validations these platforms aim to provide. While TechStep: webapp and other platforms offering peer-to-peer interactivity are potentially sources of routine social support, the unpredictable nature of user-generated content is unlikely to achieve the consistent benefits conveyed by such finely honed features as QueerViBE’s discursively grounded educational modules.

Similarly, while tips for physical safety may, or may not, be exchanged among socially networked peers, freedom from harassment and violence was the sole aim of Refuge Restrooms and U-Signal (45,47). Physical safety concerns often drive the uptake of EVA and other voice-training interventions (71). Mistrust of law enforcement is highly prevalent among TGE communities, and in particular among Black and Latinx trans communities (107), accounting for the peer-to-peer alerts enabled by U-Signal. Just as QueerViBE’s educational modules acknowledge the lived reality of stigmatization among its users, and their possible internalization of power asymmetries in a cissexist society, U-Signal acknowledges the mutually compounding systems of oppression of racism, sexism, and anti-transgender stigma for the trans-feminine users of color for whom it was designed. The HCI-derived, crowdfunded, and other non-HIV-focused interventions, in short, conceive their features in terms of resistance to the structural subordinations that drive health inequities among TGE communities. Interpreted through an imagined affordance lens, these features—and the expectations and new potentials they permit TGE users—can be understood as tools to ease the daily burden of these subordinations.

These new possibilities for self-validation, safety, and adaptive identity formation, highlight the promise of such innovative features to communities of users who share complex, distinct, and often overlapping needs. The concept of affordances, within psychology, referred originally to the instrumental possibilities of an environment, as recognized by a specific individual or group within it (50). Maintaining an imagined affordance–focused lens can aid in honing the aims of innovative features, and clarifying the insights provided by TGE communities throughout the evaluative cycle (e.g, formative, process). In short, what are the expectations and new potentials that TGE users desire of mobile, networked technologies? How does the provision of these new potentials address the health inequities endured by TGE youth, including their disparate risk of HIV acquisition? The realization of new potentials within the digitally networked environment by TGE developers, investigators, and communities, should serve to inspire the future of government-backed and university-affiliated mHealth interventions tailored to meet their needs.

Advancing the field

The landscape of TGE-responsive mobile technology, mapped in this review, points to a number of promising directions.

Knowledge exchange

Future practice and research could focus on understanding how to balance and bridge fields that often operate in siloes. The innovations advanced by TGE private-sector developers and TGE-focused investigators in HCI and social informatics suggests that a cross-sectoral stakeholder engagement or knowledge exchange model of intervention development could elicit promising new insights, while ensuring proper crediting of community-derived innovations. One such example is the mHealth intervention TreatYoSelf. While not TGE-focused, it is exemplary of such an approach, leveraging the patient-clinician-designer framework of participatory design, and allying experts in HCI with clinician-investigators in adolescent HIV (108). In capturing imagined affordances, the openly utopian “future-making” workshop process can record both the structural barriers encountered by communities attempting to realize their potential—and activate their imaginations toward surmounting those barriers with highly speculative original technologies (109).

Theoretical synthesis

The creatively realized affordances shown by the non-HIV-focused platforms are not inherently at odds with the theoretical underpinnings of much HIV-focused mHealth. Peer-to-peer empowerment, behavioral self-monitoring, and tailored informational sources are embraced across disciplines, and their potential benefits could be catalyzed by a more thorough and thoughtful grounding in health behavior change theories.

Functional integration

With the HIV-focused platforms often feature rich, and the non-HIV-focused platforms often lean but highly innovative, opportunities for high-impact functional integration may present themselves. Some instances of such convergent functionality, aligning HIV- and non-HIV-focused developments, are evident already: TechStep: webapp, for example, mimics the full functionality of Trans Memo, via its customizable behavioral trackers. But with accessibility for at-risk and under-resourced users tied to leanness [versus “feature creep” (110)], calibrating the balance versus over-proliferation of features will remain an important goal.

Outcomes evaluation

Multi-center longitudinal RCTs are often not accessible, nor appropriate, for all platforms. However, evaluations of desired outcomes, such as pre- and post-test designs, and explorations of acceptability, usability, and sustainable socio-cultural attunement (e.g, the incorporation of fast-evolving linguistic norms across TGE youth communities) can build a case for functional integration with feature-rich, evidence-based, mHealth interventions.


There are several noteworthy limitations. The timeframe within which this review was conducted limited the state of the evidence we were able to present. With findings of acceptability, feasibility, and ultimately efficacy more fully reported, the foundations for the recommendations offered here may shift substantially. Similarly, we were unable to capture the abrupt scaling up of telemedicine opportunities, including for TGE patients, which has occurred in response to the COVID-19 pandemic of 2020 (66,67). Furthermore, time and resource constraints prevented us from undertaking the optional expert consultation exercises recommended by Arksey and O’Malley (52,53). Given the nascent and discontinuous advances we aimed to map in this review, such an exercise would be especially conducive to bridging knowledge bases. As such, our results should be understood as a selective and vision-setting overview of an evolving field, rather than an integrative review of methodology or efficacy.


TGE adolescents and emerging adults endure disproportionate rates of HIV-acquisition risk, violence, and emotional distress. While networked and mobile technologies carry risks of their own, their outsized adoption by TGE youth points toward promising mHealth modalities. By aligning the micro-targeted socio-cultural attunements of community-backed interventions with the robust scientific infrastructures of government-funded HIV prevention and care programming, strides in acceptability, feasibility, and lasting utility can be achieved.


The authors would like to thank AvaGrace Palazzolo and Patrick George III for their aid in database searching and retrieval, and developing and triangulating the codes in Table 1. The authors also thank Dr. Sonia Lee for her support of this work.

Funding: This research was supported by a National Institutes of Health grant (U19HD089881). The content is solely the responsibility of the authors and does not represent the official views of the funding agencies. KEG acknowledges additional support from the National Institute of Mental Health (R25MH067127) and Eunice Kennedy Shriver National Institute of Child Health and Human Development (L30HD098047). CJR acknowledges additional support from the National Institute of Mental Health (P30MH58107).


Provenance and Peer Review: This article was commissioned by the Guest Editor (Lisa Hightow-Weidman) for the series “Technology-based Interventions in HIV Prevention and Care Continuum among American Youth” published in mHealth. The article has undergone external peer review.

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at The series “Technology-based Interventions in HIV Prevention and Care Continuum among American Youth” was commissioned by the editorial office without any funding or sponsorship. LHW served as the unpaid Guest Editor of the series. Dr. Hightow-Weidman reports grants from NICHD, during the conduct of the study. The authors have no other conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:


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doi: 10.21037/mhealth-20-60
Cite this article as: Skeen SJ, Cain D, Gamarel KE, Hightow-Weidman L, Reback CJ. mHealth for transgender and gender-expansive youth: harnessing gender-affirmative cross-disciplinary innovations to advance HIV prevention and care interventions. mHealth 2021;7:37.

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